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Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of alpha-ketoglutarate to citrate to support cell growth and viability
Patch formulations, by contrast, have struggled to demonstrate equivalent weight loss in published trials, with some showing only 812% reduction compared to placebo
Its use also lowers the risk of complications such as kidney disease, neuropathy, and retinopathy by reducing glycemic stress over time
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